Blood, 1973, Vol. 42, No. 5, pp. 793-797.
© 1973 American Society of Hematology, Inc.
Two Cases of Familial Erythrocytosis
With Increased Erythropoietin Activity
in Plasma and Urine
H. Yonemitsu 1,
K. Yamaguchi 1,
H. Shigeta 1,
K. Okuda 1, and
F. Takaku 1
1 First Department of Medicine, Chiba University School of Medicine, Chiba, Japan, and
the First Department of Medicine, Jichi Medical School, Tochigi, Japan.
Two brothers with familial erythrocytosis
born to parents of a consanguinous marriage are described. Two other siblings
were unaffected. There was a marked increase in erythropoietin concentration in
both the plasma and urine, suggesting that
a congenital defect led to erythropoietindependent polycythemia. Other causes of
polycythemia were excluded.
Submitted on July 24, 1972
Revised on January 2, 1973
Accepted on February 4, 1973
