Blood, 1973, Vol. 42, No. 5, pp. 799-804.
© 1973 American Society of Hematology, Inc.
A "Philadelphia-like" Chromosome Derived
From the Y in a Patient With
Refractory Dysplastic Anemia
Dorothy Warburton 1 and
Avrum Bluming 1
1 Department of Human Genetics and Development and Department of Medicine, College
of Physicians and Surgeons, Columbia University, New York, N.Y. 10032.
A small acrocentric chromosome, identical
in appearance to the Philadelphia chromosome of chronic myelocytic leukemia, was
identified in all karyotyped marrow cell
metaphases prepared from a 74-yr-old
male with refractory dysplastic anemia.
The abnormal chromosome was shown by
quinacrine fluorescent staining to be derived from a Y chromosome which has lost
the characteristic brilliantly fluorescent
material of its long arms. A normal Y
chromosome was consistently observed in
karyotypes of cultured peripheral blood
lymphocytes from this patient.
Submitted on October 26, 1972
Revised on May 11, 1973
Accepted on May 15, 1973
