Blood, 1973, Vol. 42, No. 6, pp. 919-923.
© 1973 American Society of Hematology, Inc.
Failure of Combined Factor VIII and
Cyclophosphamide to Suppress Antibody to
Factor VIII in Hemophilia
Marilyn A. Hruby 1 and
Irving Schulman 1
1 Department of Pediatrics, The Abraham Lincoln School of Medicine, University
of Illinois Medical Center, Chicago, Ill. 60612.
Two patients with hemophilia A and antifactor VIII antibodies were treated with
infusions of factor VIII concentrates and
intravenous cyclophosphamide in an attempt to suppress the antibody response.
Factor VIII levels of 23% and 95% were
achieved immediately postinfusion, and
prompt control of bleeding ensued. Sequential antibody titers demonstrated no
change in antibody response in either
patient when compared to previous studies following factor VIII infusion alone.
These results are in contrast to the previously reported suppression of factor VIII
antibody in a nonhemophilic patient using
an identical regimen.
Submitted on April 17, 1973
Revised on June 8, 1973
Accepted on June 11, 1973
