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Blood, 1974, Vol. 43, No. 1, pp. 33-38.
© 1974 American Society of Hematology, Inc.
Induction of Sustained Hemopoiesis in Fatty Marrow
Mehdi Tavassoli 1,
Alice Maniatis 1, and
William H. Crosby 1
1 L. C. Jacobson Blood Center, Scripps Clinic and Research Foundation, La Jolla, Calif.
92037.
Evacuation of the fatty marrow cavity results
in a sequence of regeneration which is associated with a phase of hemopoiesis. Hemopoietic
activity is, however, transient, being replaced
by adipose tissue, so that 6 mo after evacuation
the marrow is once again fatty. This phase of
transient hemopoiesis can be sustained by
phenylhydrazine-induced hemolytic stress. Hemolysis per se does not induce significant
hemopoietic activity in nonevacuated totally
fatty marrow.
Submitted on May 17, 1973
Revised on July 9, 1973
Accepted on July 16, 1973
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