Blood, 1974, Vol. 43, No. 2, pp. 271-276.
© 1974 American Society of Hematology, Inc.
G-6-PD Manchester: A New Variant Associated With
Chronic Nonspherocytic Hemolytic Anemia
Gillian Milner 1,
Irvine W. Delamore 1, and
Akira Yoshida 1
1 Department of Clinical Haematology, Manchester Royal Infirmary, Manchester, England,
and the Division of Medical Genetics, Department of Medicine, University of Washington, Seattle,
Wash. 98105.
A variant of glucose-6-phosphate dehydrogenase (G-6-PD) designated G-6-PD
Manchester, and associated with chronic
nonspherocytic hemolytic anemia, was
found in an English male. The electrophoretic mobility at pH 7.0 of this G-6-PD
variant is the slowest yet described.
Substrate specificity is normal but enzyme
activity is markedly inhibited by NADPH,
and this is thought to account for the severe
chronic hemolysis.
Submitted on November 7, 1972
Revised on August 3, 1973
Accepted on August 10, 1973
