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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Benz, E. J. Articles by Forget, B. G. Search for Related Content PubMed PubMed Citation Articles by Benz, E. J. Articles by Forget, B. G. Social Bookmarking                   What's this? Next Article  Absence of functional messenger RNA activity for beta globin chain synthesis in beta 0-thalassemia EJ Benz , PS Swerdlow and BG Forget Department of Medicine, Children's Hospital Medical Center, Boston, Mass. 02115. Functional human globin messenger RNA was isolated from reticulocytes of two patients with homozygous beta 0-thalassemia, three patients with sickle cell beta 0-thalassemia, and one patient doubly heterozygous for beta 0-thalassemia and hemoglobin Lepore. When incubated in the Krebs type II mouse ascites tumor-cell-free system, messenger RNA from these patients actively directed the synthesis of human beta s and/or alpha- and gamma-globin chains but failed to stimulate the synthesis of any beta A-chains, even though nonthalassemic human globin mRNA preparations consistently stimulated two to four times as much beta A- or beta S-globin chain synthesis as alpha-chain synthesis when incubated in the same system under the same conditions. These results strongly suggest that functional beta A-chain-specific globin mRNA is absent in beta 0-thalassemia. Volume 45, Issue 1, pp. 1-10, 01/01/1975 Copyright © 1975 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 1975 by American Society of Hematology         Online ISSN: 1528-0020