Intranuclear inclusions in Bence Jones lambda plasma cell myeloma
HJ Cohen and LG Lefer
Department of Medicine, Duke University Medical Center, VA Hospital,
Durham, N.C. 27705.
A patient with plasma cell myeloma producing only Bence Jones lambda
protein was found to have pale intranuclear inclusions in the majority of
the bone marrow plasma cells. These inclusions, previously undescribed in
myeloma patients producing only Bence Jones protein, contained Bence Jones
lambda protein, were non-electron dense, bound by a single membrane, and
contained no cytoplasmic structures. Intracytoplasmic inclusions were not
present, and the perinuclear cistern was not dilated. Thus, the inclusions
may represent intranuclear protein synthesis with anomalous release in the
abnormal cells.
Volume 45,
Issue 1,
pp. 131-139,
01/01/1975
Copyright © 1975 by The American Society of Hematology
