Prothrombin complex proteins as cofactors in platelet aggregation. I.
Inhibition of aggregation by antiserum
JB Miale and JW Kent
Department of Pathology, University of Miami School of Medicine, FL 33146.
Data are presented to support the concept that the vitamin K-dependent
coagulation factors are adsorbed onto the platelet membrane and that these
make up part of the "plasma atmosphere" necessary for the aggregation of
platelets by various agents. Together with evidence that other coagulation
factors also are part of the plasma atmosphere, it is suggested that the
aggregation reaction is part of the coagulation sequence. The immunologic
approach to demonstrating constituents of the platelet membrane promises to
be a highly specific technique for studying further the constituents of the
platelet membrane and their reactions in hemostasis.
Volume 45,
Issue 1,
pp. 97-106,
01/01/1975
Copyright © 1975 by The American Society of Hematology
