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Canine cyclic neutropenia: Erythropoietin and platelet cycles after bone marrow transplantation

JB Jones, RD Lange, TJ Yang, H Vodopick and ES Jones

The marrow of a dog affected with cyclic neutropenia (CN) was transplanted into an unaffected supralethally irradiated litermate. Prompt engraftment occurred, and cyclic rises and falls in numbers of platelets, reticulocytes, and granulocytes were noted in the recipient soon after engraftment. Prior to transplantation and under hypoxic conditions, the donor had serum erythropoietin (ESF) peak levels at 11- 12-day intervals. Following transplatation and under hypoxic conditions, cyclic peaks of ESF occurred in the transplanted dog.

Volume 45, Issue 2, pp. 213-219, 02/01/1975
Copyright © 1975 by The American Society of Hematology


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C. Haurie, D. C. Dale, and M. C. Mackey
Cyclical Neutropenia and Other Periodic Hematological Disorders: A Review of Mechanisms and Mathematical Models
Blood, October 15, 1998; 92(8): 2629 - 2640.
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  Copyright © 1975 by American Society of Hematology         Online ISSN: 1528-0020