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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lozzio, C. B. Articles by Lozzio, B. B. Search for Related Content PubMed PubMed Citation Articles by Lozzio, C. B. Articles by Lozzio, B. B. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome CB Lozzio and BB Lozzio A cell-line derived from a patient with chronic myelogenous leukemia (CML) is described. The new cell-line, which has over 175 serial passanges in a 3 1/2-yr period, has the following characteristics: (1) CML cells started to proliferate actively since they were first incubated in culture media. A threefold increase in the total number of cells was observed during the first seven passages; the cell population increased by a factor of 10 to 20 every 7 days from passage 8 through 85; from 20 to 40 times from passage 86 through 150, and more than 40 times after 150 passages. (2) The majority of the nononucleated cells are undifferentiated blasts. (3) The karyotype of all the cells examined show the Philadelphia (Ph1) chromosome and a long acrocentric marker plus aneuploidy. The Giemsa-banding studies identified the Ph1 chromosome as a terminal deletion of the long arm of chromosome 22:del(22)(q12) and the long acrocentric marker as an unbalanced reciprocal translocation of one chromosome 17 and the long arm of one chromosome 15. (4) The CML cells do not produce immunoglobulins, are free of mycoplasma, Epstein-Barr virus, and herpes-like virus particles. (5) CML cells have no alkaline phosphatase and myeloperoxidase activities and did not engulf inert particles. (6) Cultured CML cells provide a constant source of a specific antigen. This CML cell-line represents a unique source of CML cells with meaningful indicators of malignancy for clinical and experimental studies. Volume 45, Issue 3, pp. 321-334, 03/01/1975 Copyright © 1975 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Vande Loock, I. Decordier, R. Ciardelli, D. Haumont, and M. Kirsch-Volders An aphidicolin-block nucleotide excision repair assay measuring DNA incision and repair capacity Mutagenesis, October 20, 2009; (2009) gep039v1. [Abstract] [Full Text] [PDF] I. S. Zagon, R. N. Donahue, and P. J. 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