Inhibition of intravascular fibrin deposition by dipyridamole in
experimental animals
V Gurewich, B Lipinski and R Wetmore
Intravascular fibrin deposition was induced in rabbits by endotoxin, the
infusion of fibrin monomer (FM), and by the infusion of thrombin and EACA.
A previously developed radioisotope technique was used to measure the
fibrin deposits in various organs. Dipyridamole treatment of rabbits caused
significant inhibition of fibrin deposition in all three experimental
models. The drug also inhibited platelet consumption and, in the thrombin-
and EACA-infused animals, fibrinogen consumption as well. The results
obtained with dipyridamole were compared with the effect of thorotrast. It
was concluded from this comparison that the effect of dipyridamole could
not be attributed to inhibition of the reticuloendothelial system. It is
postulated that dipyridamole inhibits the final step at which soluble FM is
precipitated as fibrin in vivo.
Volume 45,
Issue 4,
pp. 569-575,
04/01/1975
Copyright © 1975 by The American Society of Hematology
