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Direct effects of thyroid hormones on bone marrow erythroid cells of rats
LA Malgor, CC Blanc, E Klainer, SE Irizar, PR Torales and L Barrios
A stimulatory effect on bone marrow cellularity was observed in normal and
nephrectomized rats continuously infused with T3 and T4. Results of bone
marrow studies are expressed in absolute numbers of total nucleated
erythroid cells per milligram of femoral marrow at the beginning and after
8 hr of continuous intravenous infusions. Administration of T3 and T4 to
nephrectomized rats produced a marked and significant increase in total
erythroid cells counted. After differential analyses of the nucleated
erythroid elements, a significant increase in all erythroid cell types was
also observed. Similar results were seen in a control group of rats in
which both ureters have been previously ligated and in groups of
nephrectomized rats receiving rabbit antiserum against erythropoietin
before starting the intravenous infusions of T3 and T4. These results
indicate that stimulation of marrow erythropoiesis produced by thyroid
hormones in our system is not dependent on renal or extra-renal production
of erythropoietin. The progressive introduction of T3 and T4 into the
circulation of rats with bilateral nephrectomy or ureter-ligated normal
rats, may overload the mechanism of transport of these hormones in plasma.
As a consequence, a progressive increase in free active forms of T3 and T4
in plasma may occur. Our interpretation of the present findings is that
thyroid hormones stimulate directly bone marrow erythropoiesis. This
stimulation is clearly evident when high levels of free active forms of
thyroid hormones are present in plasma.
Volume 45,
Issue 5,
pp. 671-679,
05/01/1975
Copyright © 1975 by The American Society of Hematology
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