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Hydroxyurea in the management of the hematologic complications of chronic
granulocytic leukemia
JH Schwartz and GP Cannellos
The effect of hydroxyurea in 35 patients with chronic granulocytic leukemia
(CGL), who either had entered an accelerated phase of the disease or had
experienced excessive myelosuppression following alkylating agents, was
studied. By either intravenous or oral administration, the drug was
successful in reducing peripheral leukocyte and blast counts in all cases
and in reducing splenomegaly in 13 of 17 patients. The median duration of
disease control was 75 days in myeloproliferative acceleration and 27 days
in frank blastic transformation. Mild nausea and vomiting were experienced
by most patients, but reversible bone marrow suppression occured in only
three patients. The drug proved useful in 19 patients who demonstrated
myeloproliferative acceleration, especially in controlling excessive
leukocytosis and/or thrombocytosis. Rapid reduction of an elevated blast
cell count was achieved in nine patients who presented in blastic crisis,
in an attempt to eliminate the associated risk of cerebral vascular
leukostasis. Five patients who required treatment for their disease
following splenectomy in the chronic phase were also well controlled.
Hydroxyurea appears to have a definite role in the management of these
hematologic complications of CGL.
Volume 46,
Issue 1,
pp. 11-16,
07/01/1975
Copyright © 1975 by The American Society of Hematology
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