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The relative spatial distributions of CFUs and CFUc in the normal mouse
femur
BI Lord, NG Testa and JH Hendry
Femoral bone marrow was divided longitudinally into two groups of cells of
varying size. By assaying CFU and CFU in the two zones of the marrow, their
distributions across the diameter of the femur was determined. It is shown
that the concentration of CFU increases from the femoral axis (15 CFU/105
bone marrow cells) to the bone surface (44 CFU/105 cells), obeying
approximately a square-law relationship. The CFU concentration, on the
other hand, increases from the femoral axis (32CFU/105 cells) to a peak
value (260 CFU/105 cells) at about 330 um from the axis and thence falls
off against to the bone surface (77 CFU/105 cells). Selective kinning cells
in DNA synthesis using the tritiated thymidine suicide technique, in vivo,
showed that CFU, near the bone surface are proliferating at a faster rate
than those more distant from bone, but that CFU have a fast proliferation
rate irrespective of their position in the distribution. Thus, bone marrow
cell populations are shown to conform to a well-defined spatial
organization corresponding to the chronologic relationships between marrow
cells.
Volume 46,
Issue 1,
pp. 65-72,
07/01/1975
Copyright © 1975 by The American Society of Hematology
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