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The factors controlling stem cell recirculation. II. ACTH-induced inhibition of migration of hemopoietic stem cells

GI Bezin, RM Khaitov, BB Moroz, RV Petrov and 99 Romashko

Injections of ACTH of prolonged action (twice 1.5 units per mouse) given to lethally (800 R) irradiated mice with a hind limb shielded to the middle of the tibia brought about a twofold decrease in the number of spleen colonies. ACTH injections after sublethal whole-body irradiation (600 R) did not affect the number of endogenous spleen colonies. ACTH injection of normal mice brought about a substantial decrease in the CFU content in the circulating blood at the time of increased 11-hydroxycorticosteroid concentrations in the plasma. The results obtained are interpreted as inhibition of CFU migration from a shielded area of bone marrow induced by a high 11-hydroxycorticosteroid content in the plasma that followed ACTH injections which had no mitostatic effect on CFU proliferation.

Volume 46, Issue 1, pp. 79-84, 07/01/1975
Copyright © 1975 by The American Society of Hematology


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