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Studies on a circulating anticoagulant in systemic lupus erythematosus:
evidence for inhibition of the function of activated plasma thromboplastin
antecedent (factor XIa)
H Krieger, JP Leddy and RT Breckenridge
Plasma proteins which interfere with blood coagulation have often been
described in patients with systemic lupus erythematosus (SLE). The most
frequent type interferes with the conversion of prothrombin to thrombin and
thus prolongs the prothrombin time. Infrequently, SLE patients exhibit
anticoagulants which appear to block the earlier stages of coagulation such
as those involving factor VIII or the formation of activated factor XI
(factor XIa). The anticoagulant reported here was studied by means of a
sequential clotting system utilizing crude coagulation factors and was
noted to interfere with the action of activated plasma thromboplastin
antecedent (PTA) during the activation of factor IX. This anticoagulant was
found in gamma-globulin-rich ethanol fractions of plasma. After gel
filtration, it was found principally in fractions containing IgM globulins
but also, to a lesser extent, in IgG-rich fractions. In this respect, it is
similar to anticoagulants reported in certain other cases of SLE. Attempts
to confirm the immunoglobulin nature of the anticoagulant by
immunoabsorption were, however, inconclusive
Volume 46,
Issue 2,
pp. 189-197,
08/01/1975
Copyright © 1975 by The American Society of Hematology
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