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The effect of Hydrocortisone on the kinetics of normal human lymphocytes
AS Fauci and DC Dale
Lymphocyte kinetic studies employing 51-chromium-labeled autologous
lymphocytes were performed in nine normal volunteers in order to determine
the effects of hydrocortisone administration on the recirculating versus
the nonrecirculating intravascular lymphocyte pools. Following infusion of
labeled cells, the recirculating portion of the labeled cells rapidly
equilibrated with the total intravascular lymphocyte pool and the vastly
larger total-body recirculating lymphocyte pool, so that by 1 hr following
infusion 21.8% plus or minus 3.2% of the labeled lymphocytes were left in
the circulation. Four hundred milligrams of intravenous hydrocortisone
administered 24 hr after infusion of labeled cells caused a profound but
transient lymphocytopenia which was maximal at 4 hr with return of
lymphocyte counts to normal by 24 hr after injection. Concomitant with the
lymphocytopenia there was a dramatic increase in lymphocyte specific
activity (cpm per 10-6 lymphocytes), while the total lymphocyte- associated
radioactivity remaining in the circulation was unchanged, indicating that
corticosteroid administration depleted the unlabeled recirculating cells.
As the lymphocyte counts returned to normal following hydrocortisone, the
specific activity also returned to normal. These studies indicated that
hydrocortisone administration caused a transient lymphocytopenia by a
preferential depletion of the recirculating portion of the intravascular
lymphocyte pool
Volume 46,
Issue 2,
pp. 235-243,
08/01/1975
Copyright © 1975 by The American Society of Hematology
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