The effect of carbon monoxide on red cell life span in sickle cell disease
E Beutler
Carbon monoxide at a concentration of 1000-2000 ppm was administered to
sickle cell disease patients. In each of two patients, one 51Cr red cell
survival study was carried out before CO administration, and a second study
was initiated a few days before CO administration was started. In both,
significant prolongation of red cell survival was observed, suggesting that
the rheologic properties of sickle cells were favorably influenced in vivo.
The administration of carbon monoxide is not recommended as a treatment for
sickle cell disease. However, further trials would seem to be justified if
conducted under carefully controlled conditions.
Volume 46,
Issue 2,
pp. 253-259,
08/01/1975
Copyright © 1975 by The American Society of Hematology
