Complement-sensitive red cells in aplastic anemia
I Ben-Bassat, F Brok-Simoni and B Ramot
In view of the clinical association of aplastic anemia (AA) and paroxysmal
nocturnal hemoglobinuria (PNH), the complement-dependent lysis of the
youngest red cells of AA patients was studied. A complement-sensitive
population of young red cells was found in five of six patients with AA.
These cells were rapidly cleared from the circulation and were undetectable
in the oldest cell fraction. Such cells were not found in normal controls
or in a variety of hematologic disorders, with the exception of PNH. This
study suggests that in most patients with AA, even without any clinical
manifestations of PNH, there is a population of dyserythropoietic,
short-lived complement- sensitive cells.
Volume 46,
Issue 3,
pp. 357-361,
09/01/1975
Copyright © 1975 by The American Society of Hematology