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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kazmierowski, J. A. Articles by Wolff, S. M. Search for Related Content PubMed PubMed Citation Articles by Kazmierowski, J. A. Articles by Wolff, S. M. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Chediak-Higashi syndrome: reversal of increased susceptibility to infection by bone marrow transplantation JA Kazmierowski, RJ Elin, HY Reynolds, WA Durbin and SM Wolff Transplantation of normal bone marrow to mice with the Chediak-Higashi syndrome (CHS) resulted in normal granulopoiesis and a reversal of their increased susceptibility to challenge with intravenous Candida albicans. These findings suggest that (1) the leukocyte defect in CHS can be reversed by marrow transplantation and (2) the mechanism for increased susceptibility to infection in these animals is due to a bone- marrow-derived cellular defect. Because of similarities between murine and human CHS, bone marrow transplantation might be considered as a mode of therapy in selected cases of the human disease. Volume 47, Issue 4, pp. 555-559, 04/01/1976 Copyright © 1976 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. O. Armitage Bone Marrow Transplantation N. Engl. J. Med., March 24, 1994; 330(12): 827 - 838. [Full Text]

	Copyright © 1976 by American Society of Hematology         Online ISSN: 1528-0020