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Polyamine concentrations in bone marrow aspirates of children with leukemia and other malignancies

O Rennert, T Miale, J Shukla, D Lawson and J Frias

High-pressure liquid chromatography analysis of polyamines in bone narrow from leukemic and nonleukemic subjects demonstrated increased concentrations of putrescine, spermidine, and spermine associated with increased cellularity. The most striking abnormality was the marked elevation of putrescine. Bone marrow polyamine analysis may be an adjunct for evaluation of leukemia patients.

Volume 47, Issue 4, pp. 695-701, 04/01/1976
Copyright © 1976 by The American Society of Hematology


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  Copyright © 1976 by American Society of Hematology         Online ISSN: 1528-0020