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Increase in circulating stem cells following chemotherapy in man
CM Richman, RS Weiner and RA Yankee
The number of circulating granulocytic stem cells (CFU-C) was determined by
the in vitro methylcellulose technique in cancer patients receiving
intermittent chemotherapy. In 17 patients studied prior to therapy, the
median CFU-C concentration per 2 X 10(5) mononuclear cells plated was six,
compared to a posttreatment median of 23 in 21 patients (p less than
0.001). Large numbers of stem cells were obtained by leukopheresis and
cryopreserved with a 99.5% median CFU-C recovery. Cyclical changes in the
concentration of stem cells with maximum values of 20 times baseline were
demonstrated in a patient studied at weekly intervals during multiple
courses of treatment. It was estimated that, at peak CFU-C concentrations,
a quantity of stem cells equivalent to that present in a bulk bone marrow
harvest could be obtained from the peripheral blood by a 17-liter pheresis.
These results suggest that it may be practical to obtain an adequate number
of stem cells from the peripheral blood to study autologous stem cell
infusion as a means of averting myelosuppression in patients receiving
intensive chemotherapy.
Volume 47,
Issue 6,
pp. 1031-1039,
06/01/1976
Copyright © 1976 by The American Society of Hematology
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