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Platelet inhibiton by sodium nitroprusside, a smooth muscle inhibitor
A Saxon and HE Kattlove
The effects of sodium nitroprusside (N.P.), a pure smooth muscle inhibitor,
on platelet function were studied. Platelet-rich plasmas (PRP) from normal
controls and from patients receiving N.P. were studied in vitro for
aggregation in response to adenosine diphosphate (ADP), epinephrine, and
collagen. Platelet ADP release (release reaction) was also investigated.
Normal platelets demonstrated marked inhibition of aggregation when
incubated with N.P. for 3 min. Prolonging the incubation was without
additional effect. ADP and ATP release from platelets in response to
collagen was also inhibited. PRP from patients receiving nitroprusside at
concentrations between 25 mug/min an 165 mug/min showed inhibition of
aggregation when compared to findings prior to the administration of N.P.
N.P. acts by inhibiting contractile proteins and thus platelet ADP release
and aggregation may depend on contraction of platelet smooth muscle-like
protein, thrombosthenin.
Volume 47,
Issue 6,
pp. 957-961,
06/01/1976
Copyright © 1976 by The American Society of Hematology
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