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Allogeneic marrow grafting for treatment of aplastic anemia: a follow- up on long-term survivors

R Storb, ED Thomas, CD Buckner, RA Clift, A Fefer, LP Fernando, ER Giblett, FL Johnson and PE Neiman

Eleven of twenty-four patients with severe aplastic anemia given marrow grafts from HLA-identical siblings between October 1970 and March 1973 are alive with normal marrow function and continued evidence of engraftment 3-5 yr later. Ten have been leading normal lives with no immunosuppressive or other drug therapy since day 100 postgrafting. One has had chronic graft-versus-host disease of the skin which is now slowly improving with no therapy. He returned to full-time employment in the summer of 1975. The long-term well-being of almost half of our initial patients emphasizes the importance of marrow transplantation for the treatment of severe aplastic anemia.

Volume 48, Issue 4, pp. 485-490, 10/01/1976
Copyright © 1976 by The American Society of Hematology


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