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A clinical study of the lupus anticoagulant
MA Schleider, RL Nachman, EA Jaffe and M Coleman
Eighty-three patients with circulating anticoagulants were studied at The
New York Hospital. The lupus-type anticoagulant, an inhibitor of the
prothrombin activator complex, was demonstrated in 58 patients. The
inhibitor was identified using the blood and tissue thromboplastin
inhibition tests. Inhibition by the lupus anticoagulant was augmented in
67% of these patients by a cofactor present in normal plasma. The lupus
inhibitor was detected primarily because of an unsuspected abnormal
coagulation test. One-half of the patients with the lupus-type
anticoagulant did not have systemic lupus erythematosus.
Volume 48,
Issue 4,
pp. 499-509,
10/01/1976
Copyright © 1976 by The American Society of Hematology
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