Acquired storage pool disease in platelets during disseminated
intravascular coagulation
FI Pareti, A Capitanio and PM Mannucci
A patient with clinical and laboratory evidence of disseminated
intravascular coagulation associated with deep-vein thrombosis and
pulmonary embolism developed a qualitative platelet abnormality
characterized by a defective release reaction. Second-phase aggregation
induced by ADP and adrenaline was impaired, and reduced collagen- induced
aggregation was accompanied by defective release of ADP and ATP. The
decrease in total platelet ATP and ADP, the high ATP:ADP ratio in the
presence of normal amounts of metabolic adenine nucleotides, and the low
content of serotonin associated with abnormal uptake and metabolism of the
exogenous amine suggested that the defective platelet function was due to
lack of the platelet organelles in which serotonin and nonmetabolic adenine
nucleotides are normally stored. Acquired storage pool disease is likely to
be related to exposure of circulating platelets to aggregating agents, with
their degranulation occurring during disseminated intravascular
coagulation.
Volume 48,
Issue 4,
pp. 511-515,
10/01/1976
Copyright © 1976 by The American Society of Hematology
