A platelet abnormality in the Chediak-Higashi syndrome of man
JL Costa, AS Fauci and SM Wolff
Platelets from two probands homozygous for the Chediak-Higashi syndrome
have approximately 10% of the normal number of serotonin-containing dense
bodies as visualized electron microscopically in air-dried whole mounts.
Since transport of serotonin across the platelet plasma membrane proceeds
at a normal rate, and the few dense bodies present appear to store normal
amounts of serotonin, the absence of dense bodies may account for the low
platelet serotonin values found in these patients.
Volume 48,
Issue 4,
pp. 517-520,
10/01/1976
Copyright © 1976 by The American Society of Hematology