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L Zech, C Gahrton, D Killander, S Franzen and U Haglund
The chromosomes of bone marrow cells from ten patients with polycythemia
vera (PV) were identified by Q-, G-, and C-banding techniques. Four of the
patients had received no treatment with cytotoxic drugs, while three had
received 32P only and the other three, in addition, had received busulfan
or busulfan and procarbazine. One 73- yr-old male patient treated with
venesection only for 4 yr lacked the Y chromosome and had a deletion of the
long arm of chromosome 20 (20q-) in all cells investigated. One of the
other three patients who had received no drugs had a chromosome
abnormality, but only in 1 of 19 identifiable metaphases. However, the
abnormality was the same (+9) as the most common one in treated patients.
In the group of treated patients, an extra chromosome 9 (+9) was found in
three patients, an extra chromosome 8 (+8) in one, and a deletion of the
long arm of one chromosome 20 (20q-) in one patient. Multiple aberrations
in addition to the extra chromosome 9 were found in one patient in whom the
disease had transformed into acute myeloblastic leukemia. The finding of
identical chromosomal aberrations (20q- and +9, respectively) in two
patients who had received no drugs and in four patients who had received
32P and busulfan or procarbazine favors the view that these aberrations are
specifically associated with the disease and not induced by the drugs. With
the exception of the patient with acute myeloblastic leukemia, all other
patients are alive 1-11 mo after chromosome analyses and 1-229 mo after
diagnosis.
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| Copyright © 1976 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
