|
|
 Previous Article | Table of Contents | Next Article 
Fetal erythropoiesis following bone marrow transplantation
BP Alter, JM Rappeport, TH Huisman, WA Schroeder and DG Nathan
"Fetal" erythrocytes are present in older children and certain adults with
hematologic disorders. To determine if regenerating bone marrow produces
such cells, we examined the blood of seven allogeneic bone marrow
transplant recipients. Six patients were engrafted with donor cells, while
on e patients recovered autologous bone marrow after rejection of a marrow
transplant. All seven patients had fetal hemoglobin levels of up to 10% by
100 days after transplant. In three patients, the Ggamma to Agamma ratio in
the fetal hemoglobin was "newborn", while in one it was "adult". Gamma
chain synthesis in blood and bone marrow never exceeded 20% of total
non-alpha globin synthesis. The fetal hemoglobin was heterogeneously
distributed in the cells. High titer i antigen also appeared. All fetal
characteristics declined by 200 days. Erythropoiesis during bone marrow
recovery appears to be associated with an accelerated, albeit partial,
recapitulation of ontogeny.
Volume 48,
Issue 6,
pp. 843-853,
12/01/1976
Copyright © 1976 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
W. Aerbajinai, J. Zhu, C. Kumkhaek, K. Chin, and G. P. Rodgers
SCF induces {gamma}-globin gene expression by regulating downstream transcription factor COUP-TFII
Blood,
July 2, 2009;
114(1):
187 - 194.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Oneal, N. M. Gantt, J. D. Schwartz, N. V. Bhanu, Y. T. Lee, J. W. Moroney, C. H. Reed, A. N. Schechter, N. L. C. Luban, and J. L. Miller
Fetal hemoglobin silencing in humans
Blood,
September 15, 2006;
108(6):
2081 - 2086.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Cao, G. Stamatoyannopoulos, and M. Jung
Induction of human {gamma} globin gene expression by histone deacetylase inhibitors
Blood,
January 15, 2004;
103(2):
701 - 709.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gabbianelli, U. Testa, A. Massa, O. Morsilli, E. Saulle, N. M. Sposi, E. Petrucci, G. Mariani, and C. Peschle
HbF reactivation in sibling BFU-E colonies: synergistic interaction of kit ligand with low-dose dexamethasone
Blood,
April 1, 2003;
101(7):
2826 - 2832.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gabbianelli, U. Testa, A. Massa, E. Pelosi, N. M. Sposi, R. Riccioni, L. Luchetti, and C. Peschle
Hemoglobin switching in unicellular erythroid culture of sibling erythroid burst-forming units: kit ligand induces a dose-dependent fetal hemoglobin reactivation potentiated by sodium butyrate
Blood,
June 1, 2000;
95(11):
3555 - 3561.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Garner, T. Tatu, J. E. Reittie, T. Littlewood, J. Darley, S. Cervino, M. Farrall, P. Kelly, T. D. Spector, and S. L. Thein
Genetic influences on F cells and other hematologic variables: a twin heritability study
Blood,
January 1, 2000;
95(1):
342 - 346.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
