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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Singer, J. W. Articles by Adamson, J. W. Search for Related Content PubMed PubMed Citation Articles by Singer, J. W. Articles by Adamson, J. W. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Steroids and hematopoiesis. III. The response of granulocytic and erythroid colony-forming cells to steroids of different classes JW Singer and JW Adamson Selected androgenic and nonandrogenic steroids enhance in vitro granulocytic and erythroid colony formation by mouse marrow cells, but do so by influencing either different target cells or cells in different states of cell cycle. Etiocholanolone, a naturally occurring nonandrogenic testosterone metabolite, permits cells not in active cycle to respond to colony-stimulating factor or erythropoietin. Fluoxymesterone, a synthetic androgen, appears to enhance colony growth by increasing the responsiveness of target cells to tropic stimuli. The majority of cells responding to this androgen are in active DNA synthesis. Direct comparison, however, of etiocholanolone-dependent erythroid or granulocytic colony-forming cells demonstrates nonidentity of the target cells. Thus colony-forming units responding to different classes of steroids are in different states of cell cycle and are physically separable. The enhancement of the in vitro response of colony-forming cells to regulating hormones by steroids such as etiocholanolane suggests a mechanism by which such agents may be therapeutically effective in certain cases of marrow failure in man. Volume 48, Issue 6, pp. 855-864, 12/01/1976 Copyright © 1976 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. P. GALE, R. E. CHAMPLIN, S. A. FEIG, and J. H. FITCHEN Aplastic Anemia: Biology and Treatment Ann Intern Med, October 1, 1981; 95(4): 477 - 494. [Abstract] [PDF]

	Copyright © 1976 by American Society of Hematology         Online ISSN: 1528-0020