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H Saito, G Goldsmith and R Waldmann
Fitzgerald factor (high molecular weight kininogen) is an agent in normal
human plasma that corrects the impaired in vitro surface- mediated plasma
reactions of blood coagulation, fibrinolysis, and kinin generation observed
in Fitzgerald trait plasma. To assess the possible pathophysiologic role of
Fitzgerald factor, its titer was measured by a functional clot-promoting
assay. Mean +/- SD in 42 normal adults was 0.99+/-0.25 units/ml, one unit
being the activity in 1 ml of normal pooled plasma. No difference in titer
was noted between normal men and women, during pregnancy, or after physical
exercise. Fitzgerald factor activity was significantly reduced in the
plasmas of eight patients with advanced hepatic cirrhosis (0.40+/-0.09
units/ml) and of ten patients with disseminated intravascular coagulation
(0.60+/-0.30 units/ml), but was normal in plasmas of patients with other
congenital clotting factor deficiencies, nephrotic syndrome, rheumatoid
arthritis, systemic lupus erythematosus, or sarcoidosis, or under treatment
with warfarin. The plasmas of 21 mammalian species tested appeared to
contain Fitzgerald factor activity, but those of two avian, two repitilian,
and one amphibian species did not correct the coagulant defect in
Fitzgerald trait plasmas.
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| Copyright © 1976 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
