Evidence suggesting the regulation of a coagulation factor levels in
rabbits by a transferable plasma agent
EW Friedman, M Karpatkin and S Karpatkin
New Zealand white rabbits were given 30 ml of goat serum intravenously.
This procedure resulted in an immediate decrease in platelet count,
fibrinogen, and levels of coagulation factors II, V, VII, and X, due to
consumption coagulopathy. These factors returned toward baseline levels
approximately 12 hr after the injection. Plasma from rabbits who had
received goat serum 48 hr previously (donor rabbits) was injected into
recipient rabbits. This procedure resulted in a slight rise in the level of
coagulation factor II (range, 20%-30%) and a significant rise in factors V
(35%-75%), VII (35%-235%), and X (35%-75%) in the recipients. When plasma
from control donor rabbits who had not received goat serum was injected
into recipients, there was no change in these coagulation factors. It is
postulated that the reduction in coagulation factor levels in donor rabbits
induces a "coagulopoietin" for each factor or one "coagulopoietin" for all
factors which stimulates increased synthesis and/or release of these
factors in recipient rabbits.
Volume 48,
Issue 6,
pp. 949-954,
12/01/1976
Copyright © 1976 by The American Society of Hematology
