Ph1-positive acute lymphocytic leukemia with chromosome 7 abnormalities
EM Mandel, F Shabtai, U Gafter, B Klein, I Halbrecht and M Djaldetti
A 56-yr-old woman with acute lymphocytic leukemia showed the presence of a
Philadelphia chromosome in 90% of the bone marrow metaphases and in 10% of
the peripheral blood metaphases. Part of the long arm of a G22 chromsome
was translocated to the long arm of a C9 chromosome. A second cytogenetic
abnormality was found in chromosome 7. Monosomy 7 was found in 60% of the
marrow and in 20% of the peripheral blood metaphases. Chromosome 7q- was
also found in a small percentage of the metaphases examined. Three months
later, when the patient was in partial remission, only 10% of the marrow
cells showed chromosome 7 monosomy and a Ph1 chromosome. During complete
remission, no chromosomal abnormalities were found, except for a high
breakage rate. The finding of a Ph1 chromosome in acute lymphocytic
leukemia indicates that different precursors, both granulocytic and
lymphocytic, may be involved in the Ph1 process.
Volume 49,
Issue 2,
pp. 281-287,
02/01/1977
Copyright © 1977 by The American Society of Hematology
