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Combination chemotherapy of advanced non-Hodgkin lymphoma with bleomycin,
adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP)
AT Skarin, DS Rosenthal, WC Moloney and E Frei
Seventy-three patients with advanced non-Hodgkin lymphoma were treated with
bleomycin, Adriamycin, cyclophosphamide, vincristine (Oncovin) and
prednisone (BACOP), administered intensively during a 7-wk induction course
followed by intermittent cycles every 3 wk for a total of 28 wk. The
objective response in 44 evaluable nonleukemic patients with diffuse
histology was 86%, with 66% achieving a complete remission (CR), varying
from 80% for diffuse poorly differentiated lymphocytic (DPDL) to 56% for
diffuse histiocytic (DH) lymphoma. In patients with nodular histology 89%
(8/9) achieved a CR with a projected 75% of patiients in CR at 14 mo.
Median follow-up from time of CR for nodular histology was 17 mo. The
projected median duration of CR in diffuse histology was 14 mo. with median
survival 14 mo. Patients with a partial response survived a median of 7 mo,
compared to 3 mo for nonresponders. Of 29 patients with diffuse histology,
17 (59%) have remained disease free for 5-34 mo with a median follow-up of
12 mo. Survival beyond 20 mo has been projected for 42% of patients with
diffuse histology (58% with DPDL and 32% with DH). The central nervous
system (CNS) was involved in a total of 11/44 (25%) patients with diffuse
histology, including 5 with primary CNS relapse. BACOP resulted in a higher
CR rate and longer survival than a previous three-drug program (COP),
especially in patients with diffuse histology.
Volume 49,
Issue 5,
pp. 759-770,
05/01/1977
Copyright © 1977 by The American Society of Hematology
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