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Blood, 1950, Vol. 5, No. 5, pp. 434-448.
© 1950 American Society of Hematology, Inc.
THROMBOTIC THROMBOCYTOPENIC PURPURA
II. STUDIES ON THE HEMOLYTIC SYNDROME IN THIS DISEASE
KARL SINGER M.D.1,
ARNO G. MOTULSKY M.D.1, and
JACOB N. SHANBERGE M.D.1
1 Department of Hematologic Research and the Department of Pathology, Medical Research
Institute, Michael Reese Hospital, Chicago, Ill. The departments are in part supported by the Michael
Reese Research Foundation, and the Department of Hematologic Research also by the Hematology Research Foundation.
Thrombotic thrombocytopenic purpura (generalized platelet thromboses) is an
acute febrile disease characterized by a diagnostic triad: thrombocytopenic purpura,
hemolytic anemia, and transitory focal neurologic signs. Twenty cases with this
condition have been reported so far. Another case is described in which the diagnosis was made ante mortem on the basis of the above criteria. Detailed hematologic, immunologic, and pigmentary studies revealed a hemolytic process unaccompanied by evidence of autoimmunization. The differential diagnosis, etiologic
factors, and pathologic physiology of the disease are discussed together with the
possibility that a hypersensitivity reaction might be present.
Note:
ACKNOWLEDGMENT
We are very much indebted to Dr. William Brams who permitted us to study his private patient.
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