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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by WHITE, C. Articles by KLEIN, A. M. Search for Related Content PubMed PubMed Citation Articles by WHITE, C. Articles by KLEIN, A. M. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1950, Vol. 5, No. 8, pp. 723-731. © 1950 American Society of Hematology, Inc. THE EFFECT OF ADMINISTRATION OF EPINEPHRINE ON THE LEUKOCYTE COUNTS OF NORMAL SUBJECTS COLIN WHITE M.Sc., M.B., B. SURG.1, TSUIN HWA LING M.D.1, and ARNOLD M. KLEIN A.B.1 1 Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, Pa. 1. Thirty-seven normal subjects were given subcutaneous injections of epinephrine, ranging from 0.25 to 0.5 mg., and the effects on the leukocytes were noted. 2. The neutrophils rose steadily for the three and one-half hours during which blood counts were made. The small lymphocytes rose in the first half hour, then fell below normal and finally returned towards normal. The eosinophils rose at first and then fell below normal for the remainder of the period. 3. The three doses of epinephrine used produced effects which differed quantitatively but not qualitatively. The most readily identified effect of the smallest dose was the one-half hour rise in lymphocytes or the one-half hour rise in total count. A dose of 0.5 mg. is satisfactory for work of this kind. 4. Subjects with a history of allergy showed a greater tendency than the remainder to exhibit a one-half hour rise in the eosinophil count. 5. The changes in the leukocyte count produced by epinephrine are similar to, but not identical with, those produced by adrenocortical hormone or adrenocorticotropic hormone. Note: ACKNOWLEDGMENTS We are indebted to the Faculty Research Committee of the University of Pennsylvania for a grant to one of us (C. W.) towards the expenses of this investigation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. J. L. M. SOME OBSERVATIONS ON THE EOSINOPHIL Ann Intern Med, October 1, 1950; 33(4): 1054 - 1060. [Abstract] [PDF]

	Copyright © 1950 by American Society of Hematology         Online ISSN: 1528-0020