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Plasma thromboplastin antecedent (PTA, factor XI): a specific and sensitive
radioimmunoassay
H Saito and GH Goldsmith
A specific, sensitive, and reproducible radioimmunoassay for human plasma
thromboplastin antecedent (PTA, factor XI) has been developed with purified
PTA and monospecific rabbit antiserum. Precise measurements of PTA antigen
were possible for concentrations as low as 0.3% of that in normal pooled
plasma. Normal plasma contained approximately 6 microgram PTA/ml. A good
correlation (correlation coefficient 0.68) existed between the PTA
procoagulant assays and radioimmunoassays among 50 normal adults (25 males
and 25 females). PTA antigen was markedly reduced in plasma of 13 patients
with congenital homozygous PTA deficiency (range less than 0.003-0.128
U/ml) and 9 patients with hepatic cirrhosis (0.35+/-0.17 U/ml), but was
normal in those of 9 patients under treatment with warfarin, 8 patients
with disseminated intravascular coagulation and 16 patients with other
congenital clotting factor abnormalities, including prekallikrein
deficiency (Fletcher trait) and high molecular weight kininogen deficiency
(Fitzgerald trait).
Volume 50,
Issue 3,
pp. 377-385,
09/01/1977
Copyright © 1977 by The American Society of Hematology
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