Prognostic significance of thrombocytosis in idiopathic sideroblastic
anemia
RR Streeter, CA Presant and E Reinhard
In order to determine the prognostic significance of thrombocytosis in
idiopathic sideroblastic anemia, the clinical courses of 17 patients were
reviewed. Six patients (36%) had thrombocytosis, and none developed acute
leukemia. Nine patients (53%) had normal platelet counts, and one developed
acute leukemia. Two patients (12%) were thrombocytopenic, and one died of
acute leukemia. There was little correlation between survival and platelet
count. Sixty-three additional case reports of idiopathic sideroblastic
anemia were collected from the literature. Analysis of those patients and
the patients in the present study documented transformation to acute
leukemia in 5 of 9 (56%) thrombocytopenic patients, 4 of 54 (7.4%) patients
with normal platelet counts, and 0 of 17 patients with thrombocytosis (p
less than 0.05). Therefore patients with idiopathic sideroblastic anemia
and thrombocytosis appear to have a decreased likelihood of leukemic
transformation.
Volume 50,
Issue 3,
pp. 427-432,
09/01/1977
Copyright © 1977 by The American Society of Hematology
