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Effect of blood donation on iron stores as evaluated by serum ferritin
CA Finch, JD Cook, RF Labbe and M Culala
Serum ferritin was measured in 2982 blood donors. First-time male donors
had a geometric mean of 127 microgram/liter and female donors 46
microgram/liter. While values were essentially constant in the women
between the ages of 18 and 45, there was a rapid increase in the men
between 18 and 30 years of age consistent with the establishment of iron
stores during that time. Blood donation was associated with a decrease in
serum ferritin. One unit per year, equivalent to an increased requirement
of 0.65 mg/day, halved the serum ferritin level in the male. More frequent
donations were associated with further decreases. From the data obtained it
would appear that male donors, while depleting their iron stores, were able
to donate 2-3 U/yr without an appreciable incidence of iron deficiency.
Women could donate only about half that amount, and more frequent donations
were associated with a high incidence of iron deficiency and donor dropout.
These data have provided information on the effect of graded amounts of
iron loss through bleeding on iron balance.
Volume 50,
Issue 3,
pp. 441-447,
09/01/1977
Copyright © 1977 by The American Society of Hematology
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