Granulopoietic and erythropoietic activity in patients with anemias of iron
deficiency and chronic disease
T Mahmood, WA Robinson, JE Kurnick and R Vautrin
The serum levels of granulocyte colony-stimulating factor (CSF) and
erythropoietin (Ep) were measured in 16 patients with iron-deficiency
anemia and 15 patients with the anemia of chronic disease. Levels of both
CSF and Ep in the serum of patients with iron-deficiency anemia had an
inverse linear relationship to the level of the packed cell volume (PCV).
There was no correlation between PCV and the levels of CSF or Ep in the
serum of patients with the anemia of chronic disease. The similarity in the
behavior of CSF and Ep in iron-deficiency anemia suggests that they may be
influenced by similar control mechanisms or have a common cellular or
molecular source.
Volume 50,
Issue 3,
pp. 449-455,
09/01/1977
Copyright © 1977 by The American Society of Hematology
