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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Godet, J. Articles by Tolstoshev, P. Search for Related Content PubMed PubMed Citation Articles by Godet, J. Articles by Tolstoshev, P. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  beta-O-thalassemia from Algeria: genetic and molecular characterization J Godet, G Verdier, V Nigon, M Belhani, F Richard, P Colonna, J Mitchell, R Williamson and P Tolstoshev beta-Thalassemia is a major public health problem in Algeria. During a survey, a family including two cases of betaO-thalassemia was studied. The family study indicated that two of the affected siblings had homozygous beta-thalassemia; there were also both normal and heterozygous siblings, and both parents had beta-thalassemia trait. In the two cases of betaO-thalassemia there was no hemoglobin A in the peripheral blood, and no beta-globin chain synthesis in whole cell incubations. Hybridization of purified complementary DNA specific for alpha- and beta-globin messenger RNAs demonstrated less than 1% mRNAbeta relative to mRNAalpha in circulating reticulocytes, and for one case in total RNA from bone marrow. There is no apparent beta- globin gene deletion as determined by hybridization in globin cDNAbeta sequence excess. Therefore the Algerian cases studied are similar in molecular pathology to some Southern Italian and Asian cases described previously, and differ from other Italian and Chinese betaO- thalassemias, in which hybridizable mRNAbeta has been demonstrated, and from deltabetaO-thalassemia, which is caused by a gene deletion. Volume 50, Issue 3, pp. 463-470, 09/01/1977 Copyright © 1977 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. G. FORGET Molecular Genetics of Human Hemoglobin Synthesis Ann Intern Med, October 1, 1979; 91(4): 605 - 616. [Abstract] [PDF]

	Copyright © 1977 by American Society of Hematology         Online ISSN: 1528-0020