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Concentration gradient of blood stem cells in mouse bone marrow--an open question

MA Maloney, RA Lamela, MJ Dorie and HM Patt

The distribution of pluripotential blood stem cells (CFU-S) in bone marrow was studied in four strains of mice. Analyses of paired samples containing various fractions of axial and marginal bone marrow cells, as well as longitudinal 200-micrometer sections, revealed a rather uniform spatial distribution of CFU-S across the diameter of the femoral medullary cavity, in contrast to the finding by others of a CFU- S concentration gradient extending from the endosteum to the central longitudinal axis of bone marrow. The existence of a stem cell gradient is therefore open to question.

Volume 51, Issue 3, pp. 521-525, 03/01/1978
Copyright © 1978 by The American Society of Hematology


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  Copyright © 1978 by American Society of Hematology         Online ISSN: 1528-0020