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Three stages of erythropoietic progenitor cell differentiation
distinguished by a number of physical and biologic properties
CJ Gregory and AC Eaves
Previous studies have shown that erythroid precursors at sequential stages
of differentiation along the red cell pathway can be distinguished by
differences in the size and maturation kinetics of the colonies to which
they give rise in vitro. Using criteria based on these two parameters, it
is thus possible to identify three distinct erythroid progenitor cell
populations in the mouse, known as day 8 BFU- E, day 3 BFU-E, and CFU-E.
These cell types have now been shown to differ in a number of other
respects, including progenitor cell size, sensitivity to cycle-active
agents, response to plethora, and effects of the W/Wv genotype. In
addition, a comparison of the differences found between day 8 BFU-E and day
3 BFU-E on one hand and those distinguishing day 3 BFU-E and CFU-E on the
other provides support for the view that early erythropoietic cell
differentiation involves a series of changes that take place long before
competence to synthesize hemoglobin becomes manifest.
Volume 51,
Issue 3,
pp. 527-537,
03/01/1978
Copyright © 1978 by The American Society of Hematology
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