Monocyte-mediated inhibition of lymphocyte blastogenesis in Hodgkin disease
GP Schechter and F Soehnlen
Mononuclear leukocytes isloated from the blood of previously treated
patients with advanced active Hodgkin disease contained high concentrations
of monocytes and showed poor lymphocyte blastogenesis to mitogens. In five
of eight patients with disseminated disease, blastogenesis became normal or
improved markedly when the leukocyte suspensions were depleted of monocytes
before culture. Addition of autologous macrophages to the monocyte-depleted
lymphocytes resulted in a reappearance of the inhibition of blastogenesis.
Monocyte inhibition was associated with the presence of active disease,
lymphocytopenia, and low lymphocyte/monocyte ratios in the peripheral
blood. The role of previous treatment is uncertain, since inhibition tended
to disappear when the patients were retreated. Inhibitory
monocyte-lymphocyte interactions may be one of the causes of impaired
cell-mediated immunity in Hodgkin disease.
Volume 52,
Issue 2,
pp. 261-271,
08/01/1978
Copyright © 1978 by The American Society of Hematology
