Ultrastructural study of acute lymphocytic leukemia: comparison with
immunologic studies
AD Glick, BK Vestal, JM Flexner and RD Collins
Leukemic cells from 29 cases of acute lymphocytic leukemia (ALL), studied
for T and B cell markers by the use of sheep erythrocyte rosetting and
surface immunoglobulin determinations, were examined by electron
microscopy. The majority of patients (76%) were found to have non-T, non-B
neoplasms composed predominantly of relatively small, inactive-appearing
cells with frequent nuclear folds. T cell cases (21%) were associated with
mediastinal masses and were predominantly composed of large,
active-appearing cells with nuclear irregularity and little rough
endoplasmic reticulum. One case of B cell origin was not morphologically
distinct from the non-T, non-B cell cases.
Volume 52,
Issue 2,
pp. 311-322,
08/01/1978
Copyright © 1978 by The American Society of Hematology
