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Decrease of mast cells in W/Wv mice and their increase by bone marrow
transplantation
Y Kitamura, S Go and K Hatanaka
Production of tissue mast cells was evaluated in genetically anemic mice of
W/Wv genotype and was found to be abnormal. In the skin of adult W/Wv mice
the number of mast cells/cm was less than 1% of the number observed in the
congeneic +/+ mice. No mast cells were detectable in other tissues of the
W/Wv mice. After transplantation of bone marrow cells from +/+ mice the
number of mast cells in the skin, stomach, caecum, and mesentery of the
W/Wv mice increased to levels similar to those of the +/+ mice. These
results show that the W/Wv mouse is a useful tool for the investigations
concerning the physiologic roles and the origin of mast cells.
Volume 52,
Issue 2,
pp. 447-452,
08/01/1978
Copyright © 1978 by The American Society of Hematology

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