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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Como, R. M. Articles by Graze, P. R. Search for Related Content PubMed PubMed Citation Articles by Como, R. M. Articles by Graze, P. R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Emergence of a cell line with extreme hypodiploidy in blast crisis of chronic myelocytic leukemia RM Como and PR Graze Cytogenetic studies in a patient with chronic myelocytic leukemia (CML) demonstrated the emergence of an extremely hypodiploid cell line at the time of blast crisis, a modal chromosome number of 35, with the modal karyotype 35,XY, -3, -4, -5, -7, -9, -11, -12, -13, -15, -16, -17, -19, -20, -22, + t(9;22) (q34;q11, + Mar1, + Mar2, + Mar3. Giemsa-banding confirmed complex chromosome rearrangements and demonstrated distinct banding patterns for the marker chromosomes. Cytologic characteristics of the leukemia blasts were predominantly myeloid. There was no important clinical response to chemotherapy, including vincristine and prednisone, or to radiotherapy. Volume 53, Issue 4, pp. 707-711, 04/01/1979 Copyright © 1979 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 1979 by American Society of Hematology         Online ISSN: 1528-0020