Treatment of refractory splenomegaly in myeloproliferative disease by
splenic artery infusion
GP Canellos, SB Sutliffe, VT DeVita and TA Lister
Five patients in the blastic phase of chronic granulocytic leukemia with
massive splenomegaly were treated by intraarterial splenic artery infusion
of cytosine arabinoside. All patients had massive splenomegaly associated
with pain and/or hypersplenism and were refractory to previous therapy. All
5 patients demonstrated responses to treatment, with reduction in spleen
size as well as symptomatic relief. Systemic toxicity was minimal in 4 of
the 5 patients.
Volume 53,
Issue 5,
pp. 1014-1017,
05/01/1979
Copyright © 1979 by The American Society of Hematology
