Salicylate blockade of granulocyte adherence and the inflammatory response
to experimental peritonitis
PJ Spagnuolo and JJ Ellner
Aspirin profoundly inhibited the in vitro augmentation of human and mouse
granulocyte adherence to nylon fiber induced by the bacterial products
Escherichia coli endotoxin and Staphylococcus aureus culture filtrate.
Granulocytes obtained from normal volunteers during the 48 hr following
ingestion of aspirin did not respond normally to endotoxin stimulation.
Furthermore, pretreatment of mice with sodium salicylate prior to
intraperitoneal infection with Streptococcus pneumoniae impaired
granulocyte exudation and resulted in uncontrolled bacteremia and greater
lethality of infection.
Volume 53,
Issue 5,
pp. 1018-1022,
05/01/1979
Copyright © 1979 by The American Society of Hematology