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Granulocyte function during lithium therapy

MS Cohen, B Zakhireh, JA Metcalf and RK Root

Random migration, chemotaxis, phagocytosis, and bactericidal ability of neutrophils from 5 patients receiving lithium carbonate were compared with those of neutrophils from healthy donors. These cells functioned normally in all respects. Neither sera from patients receiving lithium carbonate nor the addition of lithium chloride to control cells in vitro significantly altered their functional capacity. These findings suggest that neutrophil function in patients receiving lithium therapy is preserved, and they support the potential utility of this drug as a leukopoietic agent in neutropenic states.

Volume 53, Issue 5, pp. 913-915, 05/01/1979
Copyright © 1979 by The American Society of Hematology


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